{"product_id":"ace-031","title":"ACE-031","description":"\u003cp\u003e\u003cspan\u003eACE-031\u003c\/span\u003e\u003cspan\u003e (also known as ACVR2B-Fc) is an engineered fusion protein designed as a soluble decoy receptor that inhibits \u003c\/span\u003e\u003cspan\u003emyostatin\u003c\/span\u003e\u003cspan\u003e (GDF-8) and other related signaling proteins in the Transforming Growth Factor-beta (TGF-\u003c\/span\u003e\u003cspan\u003e\\beta\u003c\/span\u003e\u003cspan\u003e) superfamily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOriginally developed by Acceleron Pharma and Shire to treat muscle-wasting diseases like Duchenne Muscular Dystrophy (DMD), ACE-031 is widely known in research circles as one of the most potent \u003c\/span\u003e\u003cspan\u003emyostatin inhibitors\u003c\/span\u003e\u003cspan\u003e ever produced.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHow ACE-031 Works: The Decoy Mechanism\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMyostatin is a naturally occurring protein that acts as the body’s \"brakes\" on muscle growth, preventing skeletal muscle from growing excessively. Under normal conditions, myostatin circulating in the blood binds to the \u003c\/span\u003e\u003cspan\u003eActivin Type IIB Receptor (ActRIIB)\u003c\/span\u003e\u003cspan\u003e on muscle cell membranes, signaling the cell to limit muscle synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eACE-031 alters this process through a trap mechanism:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e1. \u003c\/span\u003e\u003cspan\u003eSoluble Decoy Binding:\u003c\/span\u003e\u003cspan\u003e ACE-031 consists of the extracellular binding portion of the ActRIIB receptor fused to a human antibody fragment (Fc region).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e2. \u003c\/span\u003e\u003cspan\u003eLigand Trapping:\u003c\/span\u003e\u003cspan\u003e When introduced into circulation, ACE-031 floats freely and binds to circulating myostatin, Activin A, Activin B, and GDF-11 \u003c\/span\u003e\u003cspan\u003ebefore\u003c\/span\u003e\u003cspan\u003e they can reach the actual receptors on muscle tissue.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e3. \u003c\/span\u003e\u003cspan\u003eUninhibited Growth Signal:\u003c\/span\u003e\u003cspan\u003e By trapping these growth-limiting proteins, ACE-031 effectively \"cuts the brakes,\" allowing muscle satellite cells to proliferate and hypertrophy without native biological restrictions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003enot for human consumption keep in Refrigerator after reconstitution\u003c\/p\u003e","brand":"PEPPERS EDMONTON 🇨🇦","offers":[{"title":"Default Title","offer_id":48092256075828,"sku":null,"price":100.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0774\/1711\/9796\/files\/345D9A6C-A34C-4AFB-94DA-43ECAA3F61F0.jpg?v=1785633234","url":"https:\/\/peppersedmonton.ca\/products\/ace-031","provider":"PEPPERS EDMONTON 🇨🇦","version":"1.0","type":"link"}