{"product_id":"melanotan-1-10","title":"Melanotan 1 10","description":"\u003cp\u003e\u003cspan\u003eMelanotan 1\u003c\/span\u003e\u003cspan\u003e (also known as \u003c\/span\u003e\u003cspan\u003eAfamelanotide\u003c\/span\u003e\u003cspan\u003e or \u003c\/span\u003e\u003cspan\u003eMT-1\u003c\/span\u003e\u003cspan\u003e) is a synthetic linear tridecapeptide consisting of \u003c\/span\u003e\u003cspan\u003e13 amino acids\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003eAc-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂\u003c\/span\u003e\u003cspan\u003e).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt is a modified, long-acting analogue of the naturally occurring peptide hormone \u003c\/span\u003e\u003cspan\u003e\\alpha\u003c\/span\u003e\u003cspan\u003e-MSH\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003e\\alpha\u003c\/span\u003e\u003cspan\u003e-melanocyte-stimulating hormone). It was developed to stimulate melanogenesis (skin pigmentation) to protect the skin from harmful ultraviolet (UV) radiation without requiring excessive sun exposure.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePrimary Key Mechanisms\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eMelanocortin Receptor Activation:\u003c\/span\u003e\u003cspan\u003e Melanotan 1 acts as a non-selective agonist primarily targeting \u003c\/span\u003e\u003cspan\u003eMC1R\u003c\/span\u003e\u003cspan\u003e (Melanocortin 1 Receptors) located on melanocytes in the skin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eMelanogenesis \u0026amp; Eumelanin Synthesis:\u003c\/span\u003e\u003cspan\u003e Binding to MC1R triggers intracellular cyclic AMP (cAMP) signaling, stimulating the enzyme tyrosinase. This shifts pigment production toward \u003c\/span\u003e\u003cspan\u003eeumelanin\u003c\/span\u003e\u003cspan\u003e (dark brown\/black protective pigment) rather than pheomelanin (red\/yellow pigment).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003ePhotoprotection \u0026amp; DNA Repair:\u003c\/span\u003e\u003cspan\u003e By increasing photoprotective eumelanin levels in epidermal cells, it reduces UV-induced cellular DNA damage, sunburn risk, and oxidative stress.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eStructural Stability:\u003c\/span\u003e\u003cspan\u003e Modifications to the natural \u003c\/span\u003e\u003cspan\u003e\\alpha\u003c\/span\u003e\u003cspan\u003e-MSH sequence (specifically replacing Met with Nle and L-Phe with D-Phe) grant Melanotan 1 a significantly longer biological half-life and enzymatic resistance compared to endogenous \u003c\/span\u003e\u003cspan\u003e\\alpha\u003c\/span\u003e\u003cspan\u003e-MSH.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003erefrigerate after reconstitution not for human consumption.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e","brand":"PEPPERS EDMONTON 🇨🇦","offers":[{"title":"Default Title","offer_id":48092050718772,"sku":null,"price":50.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0774\/1711\/9796\/files\/069072AE-B1B6-45AD-BBCF-26D4B411D3C7.jpg?v=1785610505","url":"https:\/\/peppersedmonton.ca\/products\/melanotan-1-10","provider":"PEPPERS EDMONTON 🇨🇦","version":"1.0","type":"link"}