{"product_id":"nad-500","title":"NAD+ 500","description":"\u003cp\u003e\u003cspan\u003eNAD+\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003eNicotinamide Adenine Dinucleotide\u003c\/span\u003e\u003cspan\u003e) is technically a \u003c\/span\u003e\u003cspan\u003ecoenzyme\u003c\/span\u003e\u003cspan\u003e rather than a peptide, though it is frequently grouped into peptide therapy protocols due to its complementary role in cellular repair, longevity, and mitochondrial optimization.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt is a critical pyridine nucleotide found in every living cell, where it serves as a central engine for mitochondrial energy production and DNA repair. Endogenous NAD+ levels decline significantly with age—dropping by up to 50% by middle age—leading to metabolic slowdown, decreased cellular energy, and impaired cellular repair.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePrimary Key Mechanisms\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eMitochondrial Energy Production (ATP Synthesis):\u003c\/span\u003e\u003cspan\u003e NAD+ acts as an essential electron carrier in cellular respiration. It shuttles high-energy electrons through the Krebs cycle and electron transport chain, converting nutrients into usable energy (\u003c\/span\u003e\u003cspan\u003eATP\u003c\/span\u003e\u003cspan\u003e).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eSirtuin Activation (Longevity Genes):\u003c\/span\u003e\u003cspan\u003e NAD+ is an obligatory substrate for \u003c\/span\u003e\u003cspan\u003esirtuins\u003c\/span\u003e\u003cspan\u003e (SIRT1–SIRT7)—a family of signaling proteins that regulate epigenetic modification, cellular aging, metabolic homeostasis, and stress resistance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eDNA Repair (PARP Pathway):\u003c\/span\u003e\u003cspan\u003e It fuels \u003c\/span\u003e\u003cspan\u003ePARP\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003epoly-ADP-ribose polymerase\u003c\/span\u003e\u003cspan\u003e) enzymes, which detect and repair single-strand DNA breaks caused by oxidative stress, UV radiation, and environmental toxins.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan class=\"Apple-converted-space\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003eNeurotransmitter \u0026amp; Cognitive Support:\u003c\/span\u003e\u003cspan\u003e Facilitates cellular communication in the central nervous system, helping regulate neuroinflammation, synaptic integrity, and mental clarity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003erefrigerate after reconstitution not for human consumption.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e","brand":"PEPPERS EDMONTON 🇨🇦","offers":[{"title":"Default Title","offer_id":48092051243060,"sku":null,"price":70.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0774\/1711\/9796\/files\/F0AF0125-E981-40E7-AB48-9010C94646CB.jpg?v=1785610861","url":"https:\/\/peppersedmonton.ca\/products\/nad-500","provider":"PEPPERS EDMONTON 🇨🇦","version":"1.0","type":"link"}