GHKCU 50

GHK-Cu (Copper Tripeptide-1) is a naturally occurring human plasma tripeptide (Glycyl-L-histidyl-L-lysine) bound to a copper(II) ion.

First isolated from human blood plasma in 1973 by Dr. Loren Pickart, GHK-Cu levels naturally decline with age—dropping from roughly 200 ng/mL at age 20 to around 80 ng/mL by age 60. It functions as a powerful signal peptide that regulates gene expression to drive tissue remodeling, wound healing, and anti-aging pathways.

Primary Key Mechanisms

 Extracellular Matrix Remodeling: GHK-Cu stimulates the synthesis of type I and type III collagen, elastin, and glycosaminoglycans (like hyaluronic acid), restoring structural firmness and density to skin and connective tissues.

 Gene Expression Regulation: Studies show GHK modulates over 4,000 human genes—upregulating tissue repair and antioxidant genes while downregulating pro-inflammatory and fibrotic pathways.

 Copper Transport & Delivery: Serves as a bio-available carrier, delivering copper (\text{Cu}^{2+}) directly into cells where it acts as an essential cofactor for key enzymes like lysyl oxidase (cross-linking collagen/elastin) and superoxide dismutase (SOD).

 Angiogenesis & Microcirculation: Promotes new capillary growth and vessel integrity at injury or treatment sites, improving oxygenation and nutrient delivery.

 Antioxidant & Anti-Inflammatory: Neutralizes free radicals and suppresses pro-inflammatory cytokines (such as IL-6 and TNF-\alpha), protecting damaged tissues from oxidative degradation.

not for human consumption refrigerate after reconstitution