ARA-290

ARA-290 (also known as Cibinetide or Pyroglutamate Helix B Surface Peptide) is an 11-amino-acid synthetic peptide derived from the erythropoietin (EPO) structure, designed specifically to target tissue protection and inflammation without stimulating red blood cell production.

Key Mechanisms & Characteristics

 Selective IRR Agonism: Binds exclusively to the Innate Repair Receptor (IRR)—a heterodimer of EPO receptor and CD131—which triggers anti-inflammatory, anti-apoptotic, and regenerative signaling pathways.

 No Hematopoietic Activity: Lacks binding affinity for the homodimeric EPO receptor, meaning it does not increase red blood cell counts, hematocrit, or blood viscosity.

 Nerve Fiber Regeneration: Researched extensively for its ability to reduce neuropathic pain and promote small fiber nerve density regeneration.

 Anti-Inflammatory Cascade: Inhibits pro-inflammatory cytokine cascades (TNF-α, IL-6, IL-1β) at injury sites.

not for human consumption. Refrigeration after reconstituting.